Cajun Chicken And Shrimp Alfredo Lasagna Rolls

Cajun Chicken And Shrimp Alfredo Lasagna Rolls is a medium American (Cajun) recipe that serves 4. 560 calories per serving. Recipe by COOKING WITH NIQUE on YouTube.

Prep: 30 min | Cook: 57 min | Total: 1 hr 42 min

Cost: $32.70 total, $8.18 per serving

Ingredients

  • 1 lb Chicken Tenders (cut into bite‑size pieces)
  • 12 oz Shrimp (peeled and deveined)
  • 8 sheets Lasagna Noodles (regular, not no‑boil)
  • 2 cup Heavy Whipping Cream (full‑fat for richness)
  • 8 oz Cream Cheese (softened to room temperature)
  • 2 cup Mozzarella Cheese (shredded)
  • 1 cup Parmesan Cheese (freshly grated)
  • 1 cup Fire‑Roasted Diced Tomatoes (include the juice)
  • 5 oz Fresh Spinach (whole bag, rinsed and roughly chopped)
  • 0.5 large Onion (diced)
  • 0.5 large Green Bell Pepper (diced)
  • 3 units Garlic Cloves (minced)
  • 2 tbsp Cajun Seasoning
  • 1 tsp Garlic Powder
  • 1 tsp Onion Powder
  • 1 tsp Sea Salt (plus to taste)
  • 0.5 tsp Black Pepper (freshly ground)
  • 2 tbsp Butter (unsalted, cut into pieces)
  • 2 tbsp All‑Purpose Flour
  • 2 tbsp Olive Oil (for sautéing chicken and shrimp)
  • 2 tbsp Fresh Parsley (chopped, for garnish)

Instructions

  1. Prep Vegetables

    Dice half a large onion and half a green bell pepper into bite‑size pieces. Rinse the bag of fresh spinach, spin dry and roughly chop. Mince three garlic cloves using a garlic press.

    Time: PT5M

  2. Season Chicken and Shrimp

    Drizzle olive oil over the chicken tenders and rub to coat. Sprinkle Cajun seasoning, garlic powder, onion powder, sea salt and black pepper, then toss to evenly coat. Repeat the same seasoning process with the shrimp.

    Time: PT5M

  3. Boil Lasagna Noodles

    Bring a large pot of salted water to a rolling boil. Add the lasagna sheets and cook for 8 minutes, or until al dente.

    Time: PT8M

    Temperature: 212°F

  4. Shock Noodles

    Drain the noodles in a colander and immediately rinse under cold water to stop cooking. Set aside.

    Time: PT2M

  5. Cook Chicken Tenders

    Heat a tablespoon of olive oil in a large skillet over medium‑high heat. Add the seasoned chicken tenders and cook without moving for 3 minutes per side, until golden and just cooked through.

    Time: PT7M

  6. Cook Shrimp

    In the same skillet, add a little butter and let it melt. Add the seasoned shrimp and cook for about 1 minute per side, just until pink and opaque.

    Time: PT2M

  7. Sauté Onions and Peppers

    Add the diced onion and bell pepper to the skillet with a splash of butter. Sauté for 1 minute until slightly softened.

    Time: PT1M

  8. Make Alfredo Sauce

    In the same pan, melt 2 tbsp butter, add minced garlic and sauté 30 seconds. Sprinkle flour over the butter and whisk for 30 seconds to form a roux. Slowly whisk in the heavy whipping cream, then stir in cream cheese, Parmesan, and mozzarella until smooth and thickened.

    Time: PT5M

  9. Chop Cooked Proteins

    Transfer the cooked chicken tenders and shrimp to a cutting board and coarsely chop them into bite‑size pieces.

    Time: PT2M

  10. Combine Filling

    In a large mixing bowl, combine the chopped spinach, softened cream cheese, sautéed onions and peppers, fire‑roasted diced tomatoes (with juice), chopped chicken, shrimp, and shredded mozzarella. Mix until evenly distributed.

    Time: PT3M

  11. Assemble Lasagna Rolls

    Spread a thin layer of Alfredo sauce on the bottom of a 9x13‑inch baking dish. Lay a lasagna noodle flat, spoon a generous amount of the filling onto one end, roll tightly, and place seam‑side down in the dish. Repeat with all noodles. Pour the remaining Alfredo sauce over the rolls and sprinkle extra mozzarella on top.

    Time: PT10M

  12. Bake

    Bake the assembled rolls in a pre‑heated oven at 375°F for 30–35 minutes, until the sauce is bubbling and the cheese is golden brown.

    Time: PT35M

    Temperature: 375°F

  13. Garnish and Serve

    Remove from oven, let rest 5 minutes, then sprinkle chopped fresh parsley over the top. Serve warm.

    Time: PT2M

Nutrition Facts

Calories
560
Protein
35 g
Carbohydrates
45 g
Fat
25 g
Fiber
4 g

Dietary info: Contains dairy, Contains gluten, Contains shellfish, Not vegan, Not vegetarian

Allergens: Dairy, Gluten, Shellfish

Last updated: April 7, 2026

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Cajun Chicken And Shrimp Alfredo Lasagna Rolls

Recipe by COOKING WITH NIQUE

A creamy, spicy twist on classic lasagna featuring Cajun-seasoned chicken tenders, succulent shrimp, spinach, fire‑roasted tomatoes, and a rich Alfredo sauce, all rolled up in lasagna noodles and baked to golden perfection.

MediumAmerican (Cajun)Serves 4

Shop all ingredients on Amazon in one click • Printable PDF with shopping checklist

Source Video
22m
Prep
1h 5m
Cook
10m
Cleanup
1h 37m
Total

Cost Breakdown

$32.70
Total cost
$8.18
Per serving

Critical Success Points

  • Season Chicken and Shrimp
  • Boil Lasagna Noodles
  • Cook Chicken Tenders
  • Cook Shrimp
  • Make Alfredo Sauce
  • Assemble Lasagna Rolls
  • Bake

Safety Warnings

  • Handle raw chicken and shrimp separately to avoid cross‑contamination.
  • Cook chicken to an internal temperature of 165°F.
  • Ensure shrimp are fully pink and opaque before removing from heat.
  • Use oven mitts when handling the hot baking dish.

Frequently Asked Questions

Everything you need to know about this recipe

Q

What is the cultural significance and history of Cajun Chicken and Shrimp Alfredo Lasagna Rolls in American Cajun cuisine?

A

Cajun cuisine originates from the French‑speaking Acadian settlers of Louisiana, known for bold spices and seafood. This dish fuses traditional Cajun seasoning with Italian lasagna techniques, showcasing the multicultural food landscape of the American South.

cultural
Q

What are the traditional regional variations of Cajun chicken and shrimp dishes in Louisiana cuisine?

A

In Louisiana, Cajun chicken is often served as a blackened or étouffée stew, while shrimp appears in gumbo, jambalaya, and po'boys. The lasagna roll version is a modern, fusion take that keeps the signature spices but presents them in a baked pasta format.

cultural
Q

How is Cajun Chicken and Shrimp Alfredo Lasagna Rolls traditionally served in Cajun households?

A

It is typically served hot from the oven, topped with fresh parsley and a side of crusty bread or a simple green salad. Families often enjoy it for weekend dinner or special gatherings, pairing it with iced tea or a light white wine.

cultural
Q

What occasions or celebrations is Cajun Chicken and Shrimp Alfredo Lasagna Rolls traditionally associated with in Cajun culture?

A

While not tied to a specific holiday, the dish is popular for casual celebrations, pot‑lucks, and family gatherings because it feeds a crowd and combines beloved Cajun flavors with comforting pasta.

cultural
Q

How does Cajun Chicken and Shrimp Alfredo Lasagna Rolls fit into the broader American Cajun cuisine tradition?

A

It reflects the Cajun love for spice, seafood, and hearty meals, while borrowing the Italian lasagna structure. The dish illustrates how Cajun flavors have been adapted into mainstream American comfort food.

cultural
Q

What are the authentic traditional ingredients for Cajun Chicken and Shrimp Alfredo Lasagna Rolls versus acceptable substitutes?

A

Authentic ingredients include Cajun seasoning, shrimp, chicken tenders, heavy cream, cream cheese, and fire‑roasted tomatoes. Substitutes can be chicken breast for tenders, scallops for shrimp, half‑and‑half for cream, or regular diced tomatoes if fire‑roasted are unavailable.

cultural
Q

What other Cajun dishes pair well with Cajun Chicken and Shrimp Alfredo Lasagna Rolls?

A

Serve with a simple Cajun coleslaw, cornbread, or a light cucumber‑tomato salad dressed with a vinaigrette. A side of dirty rice also complements the bold flavors.

cultural
Q

What makes Cajun Chicken and Shrimp Alfredo Lasagna Rolls special or unique in Cajun cuisine?

A

The dish uniquely marries the creamy richness of Alfredo sauce with the smoky heat of Cajun spices, and wraps everything in lasagna noodles, creating a handheld, baked casserole that stands out from traditional stews or rice dishes.

cultural
Q

What are the most common mistakes to avoid when making Cajun Chicken and Shrimp Alfredo Lasagna Rolls at home?

A

Common errors include overcooking the noodles, over‑seasoning the meat, overcooking shrimp, and under‑thickening the Alfredo sauce. Follow the timing cues and let the sauce simmer until it coats the back of a spoon.

technical
Q

Why does this Cajun Chicken and Shrimp Alfredo Lasagna Rolls recipe use flour to thicken the sauce instead of cornstarch?

A

Flour creates a classic roux that adds body and a silky texture to an Alfredo sauce, while cornstarch can give a glossy but slightly gummy finish. The roux also helps the sauce cling to the lasagna rolls during baking.

technical
Q

Can I make Cajun Chicken and Shrimp Alfredo Lasagna Rolls ahead of time and how should I store them?

A

Yes, you can assemble the rolls, cover them, and refrigerate for up to 24 hours before baking. For longer storage, freeze the unbaked rolls wrapped tightly in foil and bake from frozen, adding 10 extra minutes.

technical
Q

What does the YouTube channel COOKING WITH NIQUE specialize in?

A

The YouTube channel COOKING WITH NIQUE specializes in easy‑to‑follow, family‑friendly recipes that blend comfort food with bold flavors, often featuring step‑by‑step demonstrations and budget‑friendly tips.

channel
Q

How does the YouTube channel COOKING WITH NIQUE's approach to Cajun cooking differ from other Cajun cooking channels?

A

COOKING WITH NIQUE focuses on accessible home‑cooking techniques, using everyday pantry ingredients and clear visual cues, whereas many Cajun channels emphasize traditional restaurant‑style preparations or complex techniques.

channel

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