Cajun Meatloaf

Cajun Meatloaf is a medium American (Cajun) recipe that serves 6. 350 calories per serving. Recipe by All Wings Everything on YouTube.

Prep: 23 min | Cook: 1 hr 27 min | Total: 2 hrs 5 min

Cost: $14.01 total, $2.34 per serving

Ingredients

  • 1.5 lb Ground Beef (80% lean)
  • 0.5 lb Italian Sausage (spicy, removed from casing)
  • 1 cup Bread Crumbs (plain; panko can be used)
  • 1 medium Onion (diced)
  • 1 medium Green Bell Pepper (diced)
  • 2 stalks Celery (diced)
  • 3 stalks Green Onions (chopped)
  • 2 cloves Garlic (minced)
  • 2 large Eggs (beaten)
  • 0.5 cup Milk (whole or 2% works)
  • 1 tsp Olive Oil (for sautéing)
  • 2 tbsp Cajun Seasoning (Slap Ya Mama brand preferred)
  • 1 tsp Salt (Lacosta or kosher salt, to taste)
  • 0.5 tsp Black Pepper (freshly ground)
  • a pinch Cayenne Pepper (optional, for extra heat)
  • 1 tbsp Hot Sauce (your favorite brand)
  • 0.5 cup Ketchup
  • 0.25 cup Orange Juice (freshly squeezed or store‑bought)
  • 2 tbsp Brown Sugar
  • 1 tbsp Dijon Mustard
  • 1 tbsp Honey

Instructions

  1. Whisk Egg‑Milk Mixture

    Crack the two eggs into a large mixing bowl, add the ½ cup milk, and whisk until fully combined. Set aside.

    Time: PT5M

  2. Prep Vegetables

    Dice the onion, green bell pepper, and celery; chop the green onions; mince the garlic cloves.

    Time: PT5M

  3. Sauté Vegetables

    Heat a teaspoon of olive oil in a skillet over medium heat. Add the diced onion, green pepper, celery, green onions, and garlic. Cook, stirring occasionally, until softened, about 5 minutes. Season with a pinch of salt, black pepper, and optional cayenne.

    Time: PT5M

    Temperature: Medium

  4. Add Flavor Base

    Turn off the heat and stir in 1 tbsp hot sauce, 2 tbsp brown sugar, and 1 tbsp Dijon mustard. Mix until the sugar dissolves.

    Time: PT2M

  5. Combine Meats

    In a separate large bowl, add the ground beef and the crumbled spicy Italian sausage. Using clean hands, break them up and mix until just combined.

    Time: PT3M

  6. Incorporate Remaining Ingredients

    Sprinkle 2 tbsp Cajun seasoning over the meat, then add the sautéed vegetable mixture, 1 cup plain bread crumbs, and the egg‑milk mixture. Mix gently with your hands until everything is evenly distributed.

    Time: PT5M

  7. Prepare Baking Pan

    Line a 9×5‑inch loaf pan with aluminum foil, allowing excess foil to hang over the sides for easy lift. Lightly spray the foil with cooking spray.

    Time: PT2M

  8. Shape and Transfer Meatloaf

    Transfer the meat mixture into the prepared pan, pressing gently to form an even loaf about 2‑inch thick.

    Time: PT2M

  9. Make the Glaze

    In a small bowl, whisk together ½ cup ketchup, ¼ cup orange juice, 2 tbsp brown sugar, 1 tsp Cajun seasoning, and 1 tbsp honey until smooth.

    Time: PT2M

  10. Apply First Glaze Layer

    Brush about half of the glaze over the top of the meatloaf, leaving a thin layer for later basting.

    Time: PT1M

  11. Preheat Oven and Bake (First Phase)

    Preheat the oven to 400°F (200°C). Place the loaf in the center of the oven and bake for 30 minutes.

    Time: PT30M

    Temperature: 400°F

  12. Baste and Continue Baking

    Remove the loaf, brush with the remaining glaze, then return to the oven and bake an additional 25‑30 minutes, or until the internal temperature reaches 160°F (71°C).

    Time: PT30M

    Temperature: 400°F

  13. Rest the Meatloaf

    Remove the loaf from the oven, let it rest in the pan for 5‑10 minutes. Drain any excess liquid from the foil if desired.

    Time: PT10M

  14. Slice and Serve

    Using a sharp knife, slice the meatloaf into 1‑inch thick pieces. Serve warm with any remaining glaze on the side.

    Time: PT5M

Nutrition Facts

Calories
350
Protein
25 g
Carbohydrates
20 g
Fat
20 g
Fiber
2 g

Dietary info: Contains gluten, Contains dairy, Not vegetarian

Allergens: Eggs, Milk, Wheat (bread crumbs), Mustard

Last updated: April 7, 2026

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Cajun Meatloaf

Recipe by All Wings Everything

A spicy Southern‑style meatloaf packed with Italian sausage, Cajun seasoning, and a sweet‑tangy ketchup‑orange glaze. Perfect for a hearty dinner that takes classic comfort food to the next level.

MediumAmerican (Cajun)Serves 6

Shop all ingredients on Amazon in one click • Printable PDF with shopping checklist

Source Video
35m
Prep
1h 12m
Cook
13m
Cleanup
2h
Total

Cost Breakdown

$14.01
Total cost
$2.34
Per serving

Critical Success Points

  • Sauté vegetables until softened but not browned.
  • Mix meat gently to avoid a dense loaf.
  • Use a meat thermometer to ensure internal temperature reaches 160°F.
  • Rest the meatloaf before slicing to retain juices.

Safety Warnings

  • Handle hot oil carefully to avoid burns.
  • Use oven mitts when removing the hot loaf from the oven.
  • Always wash hands after handling raw meat to prevent cross‑contamination.
  • Use a calibrated meat thermometer to verify safe internal temperature.

Frequently Asked Questions

Everything you need to know about this recipe

Q

What is the cultural significance and history of Cajun Meatloaf in American Southern cuisine?

A

Cajun meatloaf blends the classic American comfort food of meatloaf with the bold, spicy flavors of Cajun cooking from Louisiana. It reflects the Southern tradition of using readily available meats and seasoning them with regional spices like Cajun blends, creating a hearty dish often served at family gatherings.

cultural
Q

What are the traditional regional variations of Cajun Meatloaf in Southern United States cuisine?

A

In Louisiana, some cooks add Andouille sausage, smoked paprika, or even crawfish tails for extra depth. In other Southern states, the glaze may feature molasses or bourbon instead of orange juice, and the seasoning can lean more toward Creole blends with thyme and oregano.

cultural
Q

How is Cajun Meatloaf traditionally served in Louisiana cuisine?

A

It is typically sliced and served with a side of creamy mashed potatoes, buttered green beans, or a simple coleslaw. The sweet‑tangy glaze is often drizzled over the slices, and a dollop of hot sauce may accompany the plate for extra heat.

cultural
Q

What occasions or celebrations is Cajun Meatloaf traditionally associated with in Southern American culture?

A

Cajun meatloaf is a popular weekend family dinner, potluck staple, and sometimes appears at casual holiday gatherings like Thanksgiving or Fourth of July barbecues where a comforting, crowd‑pleasing main is needed.

cultural
Q

What makes Cajun Meatloaf special or unique in American Southern cuisine?

A

The combination of spicy Italian sausage, Cajun seasoning, and a citrus‑sweet glaze gives the loaf a bold flavor profile that stands out from the milder, ketchup‑only meatloafs common in other regions, delivering heat, sweetness, and depth in each bite.

cultural
Q

What are the most common mistakes to avoid when making Cajun Meatloaf at home?

A

Common errors include over‑mixing the meat (which makes it tough), under‑seasoning the glaze, and not using a meat thermometer, which can lead to undercooked or overly dry meat. Also, skipping the resting step results in crumbly slices.

technical
Q

Why does this Cajun Meatloaf recipe use both ground beef and spicy Italian sausage instead of just one meat?

A

The beef provides a classic, juicy base while the spicy Italian sausage adds depth, fat, and a peppery kick that complements the Cajun seasoning. This blend creates a more complex flavor and a tender texture than using a single meat.

technical
Q

Can I make Cajun Meatloaf ahead of time and how should I store it?

A

Yes. Prepare the meat mixture up to shaping, cover, and refrigerate for up to 24 hours. After baking, let it cool, then store slices in an airtight container in the refrigerator for 3‑4 days or freeze for up to 3 months.

technical
Q

What texture and appearance should I look for when the Cajun Meatloaf is done cooking?

A

The loaf should have a caramelized, glossy glaze on top and an internal temperature of 160°F. When cut, the interior should be moist and pink‑brown, not dry or crumbly.

technical
Q

What does the YouTube channel All Wings Everything specialize in?

A

The YouTube channel All Wings Everything specializes in bold, flavorful American comfort food and wing‑centric recipes, often featuring creative twists, spicy seasonings, and approachable home‑cooking techniques.

channel
Q

How does the YouTube channel All Wings Everything's approach to Southern cuisine differ from other cooking channels?

A

All Wings Everything emphasizes high‑impact flavors like hot sauces and Cajun blends, often using simple pantry staples and focusing on quick, satisfying meals. The channel’s style is energetic, with a focus on practical tips for home cooks rather than elaborate plating.

channel

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