Mexican Chicken Bubble Up Casserole
Mexican Chicken Bubble Up Casserole is a medium Mexican recipe that serves 6. 350 calories per serving. Recipe by Gregs Cumberlachia Kitchen on YouTube.
Prep: 45 min | Cook: 55 min | Total: 1 hr 55 min
Cost: $10.32 total, $1.72 per serving
Ingredients
- 2 pieces Chicken Breast (Boneless, skinless; can use rotisserie or boiled chicken instead)
- 1 tablespoon Mrs. Dash Southwest Chipotle Salt‑Free Seasoning (Season chicken before sautéing)
- 1.5 cups Salsa (red) (Store‑bought or homemade; can substitute green salsa (salsa verde) for a tangier flavor)
- 0.75 cup Water
- 1 teaspoon Dried Oregano
- 1.5 teaspoons Garlic Powder (1 tsp for sauce, 0.5 tsp for biscuit dough)
- 1 teaspoon Paprika
- 1 can (14.5 oz) Diced Tomatoes (Drain slightly if you prefer a thicker sauce)
- 1 small can (4 oz) Green Chilies (canned, mild) (Can use hotter chilies for more spice)
- 1 cup Self‑Rising Flour (If unavailable, use all‑purpose flour + 1 tsp baking powder + pinch of salt)
- 0.5 cup Buttermilk (Provides tenderness to biscuits; can substitute milk + 1 tsp lemon juice)
- 3 cups Shredded Cheese (Mexican blend or cheddar) (Divided: 1 cup in biscuit dough, 2 cups for topping)
Instructions
Season and Sauté Chicken
Pat the chicken breasts dry, season both sides with Mrs. Dash Southwest Chipotle Salt‑Free Seasoning, then sauté in a lightly sprayed skillet over medium‑high heat until golden brown and cooked through, about 8‑10 minutes. Remove from heat and set aside.
Time: PT10M
Dice the Chicken
Transfer the cooked chicken to a cutting board and dice into bite‑size pieces (about ½‑inch cubes).
Time: PT5M
Prepare the Sauce
In a bowl combine 1½ cups salsa, ¾ cup water, 1 tsp dried oregano, 1 tsp garlic powder, 1 tsp paprika, 1 can diced tomatoes (drained slightly), and 1 can green chilies. Stir until evenly mixed.
Time: PT5M
Preheat Oven
Preheat the oven to 350°F (175°C).
Time: PT10M
Temperature: 350°F
Make Biscuit Dough
In a mixing bowl combine 1 cup self‑rising flour, 0.5 tsp garlic powder, 1 cup shredded cheese, 1 small can green chilies (drained), and ½ cup buttermilk. Stir until a thick, slightly sticky dough forms. If the dough is too runny, add a tablespoon more flour; if too dry, add a splash more buttermilk.
Time: PT15M
Shape and Cut Biscuits
Turn the dough onto a lightly floured surface, pat it to a thickness of ½‑¾ inch, and use a 2‑inch biscuit cutter (floured) to cut rounds. Gather scraps, re‑pat, and cut more biscuits until dough is used.
Time: PT5M
Assemble the Casserole
Spread the diced chicken evenly in the bottom of the 9×13‑inch casserole dish. Pour the prepared sauce over the chicken, spreading to cover. Sprinkle the remaining 2 cups shredded cheese on top. Arrange the biscuit pieces over the cheese, spacing them evenly.
Time: PT5M
Bake
Place the casserole uncovered in the preheated oven and bake for 45 minutes, or until the biscuits are golden brown and cooked through and the sauce is bubbling.
Time: PT45M
Temperature: 350°F
Cool and Serve
Remove the casserole from the oven and let it rest for 15‑20 minutes before serving. This allows the sauce to set and makes cutting easier.
Time: PT20M
Nutrition Facts
- Calories
- 350
- Protein
- 20g
- Carbohydrates
- 30g
- Fat
- 15g
- Fiber
- 3g
Dietary info: Can be made gluten‑free with gluten‑free self‑rising flour, Can be made dairy‑free using dairy‑free cheese and plant‑based milk
Allergens: Dairy, Gluten
Last updated: March 12, 2026






