Mexican Chicken Bubble Up Casserole

Mexican Chicken Bubble Up Casserole is a medium Mexican recipe that serves 6. 350 calories per serving. Recipe by Gregs Cumberlachia Kitchen on YouTube.

Prep: 45 min | Cook: 55 min | Total: 1 hr 55 min

Cost: $10.32 total, $1.72 per serving

Ingredients

  • 2 pieces Chicken Breast (Boneless, skinless; can use rotisserie or boiled chicken instead)
  • 1 tablespoon Mrs. Dash Southwest Chipotle Salt‑Free Seasoning (Season chicken before sautéing)
  • 1.5 cups Salsa (red) (Store‑bought or homemade; can substitute green salsa (salsa verde) for a tangier flavor)
  • 0.75 cup Water
  • 1 teaspoon Dried Oregano
  • 1.5 teaspoons Garlic Powder (1 tsp for sauce, 0.5 tsp for biscuit dough)
  • 1 teaspoon Paprika
  • 1 can (14.5 oz) Diced Tomatoes (Drain slightly if you prefer a thicker sauce)
  • 1 small can (4 oz) Green Chilies (canned, mild) (Can use hotter chilies for more spice)
  • 1 cup Self‑Rising Flour (If unavailable, use all‑purpose flour + 1 tsp baking powder + pinch of salt)
  • 0.5 cup Buttermilk (Provides tenderness to biscuits; can substitute milk + 1 tsp lemon juice)
  • 3 cups Shredded Cheese (Mexican blend or cheddar) (Divided: 1 cup in biscuit dough, 2 cups for topping)

Instructions

  1. Season and Sauté Chicken

    Pat the chicken breasts dry, season both sides with Mrs. Dash Southwest Chipotle Salt‑Free Seasoning, then sauté in a lightly sprayed skillet over medium‑high heat until golden brown and cooked through, about 8‑10 minutes. Remove from heat and set aside.

    Time: PT10M

  2. Dice the Chicken

    Transfer the cooked chicken to a cutting board and dice into bite‑size pieces (about ½‑inch cubes).

    Time: PT5M

  3. Prepare the Sauce

    In a bowl combine 1½ cups salsa, ¾ cup water, 1 tsp dried oregano, 1 tsp garlic powder, 1 tsp paprika, 1 can diced tomatoes (drained slightly), and 1 can green chilies. Stir until evenly mixed.

    Time: PT5M

  4. Preheat Oven

    Preheat the oven to 350°F (175°C).

    Time: PT10M

    Temperature: 350°F

  5. Make Biscuit Dough

    In a mixing bowl combine 1 cup self‑rising flour, 0.5 tsp garlic powder, 1 cup shredded cheese, 1 small can green chilies (drained), and ½ cup buttermilk. Stir until a thick, slightly sticky dough forms. If the dough is too runny, add a tablespoon more flour; if too dry, add a splash more buttermilk.

    Time: PT15M

  6. Shape and Cut Biscuits

    Turn the dough onto a lightly floured surface, pat it to a thickness of ½‑¾ inch, and use a 2‑inch biscuit cutter (floured) to cut rounds. Gather scraps, re‑pat, and cut more biscuits until dough is used.

    Time: PT5M

  7. Assemble the Casserole

    Spread the diced chicken evenly in the bottom of the 9×13‑inch casserole dish. Pour the prepared sauce over the chicken, spreading to cover. Sprinkle the remaining 2 cups shredded cheese on top. Arrange the biscuit pieces over the cheese, spacing them evenly.

    Time: PT5M

  8. Bake

    Place the casserole uncovered in the preheated oven and bake for 45 minutes, or until the biscuits are golden brown and cooked through and the sauce is bubbling.

    Time: PT45M

    Temperature: 350°F

  9. Cool and Serve

    Remove the casserole from the oven and let it rest for 15‑20 minutes before serving. This allows the sauce to set and makes cutting easier.

    Time: PT20M

Nutrition Facts

Calories
350
Protein
20g
Carbohydrates
30g
Fat
15g
Fiber
3g

Dietary info: Can be made gluten‑free with gluten‑free self‑rising flour, Can be made dairy‑free using dairy‑free cheese and plant‑based milk

Allergens: Dairy, Gluten

Last updated: April 19, 2026

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Mexican Chicken Bubble Up Casserole

Recipe by Gregs Cumberlachia Kitchen

A hearty Mexican‑style casserole layered with seasoned chicken, tangy salsa‑tomato sauce, and fluffy buttermilk biscuits that rise up through the bubbling sauce. Perfect for a family dinner or a crowd‑pleasing potluck.

MediumMexicanServes 6

Shop all ingredients on Amazon in one click • Printable PDF with shopping checklist

Source Video
1h
Prep
1h
Cook
14m
Cleanup
2h 14m
Total

Cost Breakdown

$10.32
Total cost
$1.72
Per serving

Critical Success Points

  • Season and fully cook the chicken before adding to the casserole.
  • Ensure biscuit dough is thick enough; too thin dough will result in soggy biscuits.
  • Bake uncovered until biscuits are golden and fully cooked; cover with foil only if they brown too fast.

Safety Warnings

  • Handle the hot skillet and oven with oven mitts to avoid burns.
  • Ensure chicken reaches an internal temperature of 165°F (74°C) for safe consumption.
  • Watch the casserole while baking to prevent over‑browning or burning.

Frequently Asked Questions

Everything you need to know about this recipe

Q

What is the cultural significance and history of Mexican Bubble Up Casserole in American‑Mexican cuisine?

A

The bubble‑up casserole is a modern, comfort‑food twist on traditional Mexican layered dishes like enchilada casseroles. It reflects the American love for hearty, one‑dish meals while incorporating classic Mexican flavors such as salsa, chilies, and cheese.

cultural
Q

What are the traditional regional variations of Mexican Bubble Up Casserole in Mexican‑inspired cuisine?

A

While the bubble‑up casserole itself is a contemporary creation, similar layered dishes appear in the Southwest United States, often using corn tortillas instead of biscuits. In northern Mexico, a version might include chorizo and a spicier salsa verde.

cultural
Q

How is Mexican Bubble Up Casserole traditionally served in Mexican‑American households?

A

It is typically served hot straight from the oven, often accompanied by fresh toppings like cilantro, avocado slices, sour cream, or extra salsa. It makes a complete meal on its own or can be paired with a simple side salad or Mexican rice.

cultural
Q

What occasions or celebrations is Mexican Bubble Up Casserole traditionally associated with in Mexican‑American culture?

A

Because it feeds a crowd, it’s popular for family gatherings, potlucks, game‑day parties, and casual holiday meals such as Cinco de Mayo or Fourth of July barbecues.

cultural
Q

What makes Mexican Bubble Up Casserole special or unique in Mexican‑American cuisine?

A

The defining feature is the biscuit topping that rises through the bubbling salsa‑tomato sauce, creating a fluffy, golden crust that contrasts with the savory chicken and cheese underneath—a texture not found in classic enchiladas.

cultural
Q

How has Mexican Bubble Up Casserole evolved over time in home cooking circles?

A

Home cooks have adapted the recipe by swapping biscuits for corn‑meal dumplings, using different proteins like shredded pork, and adding vegetables such as corn or black beans, showing the dish’s flexibility and growing popularity.

cultural
Q

What are the most common mistakes to avoid when making Mexican Bubble Up Casserole at home?

A

Common errors include over‑mixing the biscuit dough, using too much liquid in the sauce, and under‑baking the biscuits which leaves a doughy center. Also, forgetting to preheat the oven can result in uneven cooking.

technical
Q

Why does this Mexican Bubble Up Casserole recipe use self‑rising flour instead of all‑purpose flour with separate leavening?

A

Self‑rising flour simplifies the biscuit dough by already containing the right amount of baking powder and salt, ensuring consistent rise without having to measure additional leavening agents.

technical
Q

Can I make Mexican Bubble Up Casserole ahead of time and how should I store it?

A

Yes. Assemble the casserole up to the point of adding the biscuit topping, cover, and refrigerate for up to 24 hours. Bake directly from the fridge, adding 5‑10 minutes to the baking time. Leftovers store in the refrigerator for 4 days or freeze for up to 2 months.

technical
Q

What does the YouTube channel Gregs Cumberlachia Kitchen specialize in?

A

Gregs Cumberlachia Kitchen focuses on approachable, family‑friendly comfort food recipes, often featuring creative twists on classic dishes and collaborative “casserole” projects with other creators.

channel
Q

How does the YouTube channel Gregs Cumberlachia Kitchen's approach to Mexican‑inspired cooking differ from other Mexican cooking channels?

A

Gregs Cumberlachia Kitchen blends traditional Mexican flavors with American comfort‑food techniques, such as using biscuit toppings, whereas many Mexican‑focused channels stick to authentic preparations like tacos, enchiladas, and mole sauces.

channel

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