Easy Cheesy Bubble Up Chicken Casserole

Easy Cheesy Bubble Up Chicken Casserole is a easy Southern American recipe that serves 6. 460 calories per serving. Recipe by TENNESSEE NIKKI on YouTube.

Prep: 20 min | Cook: 50 min | Total: 1 hr 20 min

Cost: $15.49 total, $2.58 per serving

Ingredients

  • 3 cups Rotisserie Chicken (Shredded breast meat only)
  • 2 cans Cream of Chicken Soup (10.5‑oz cans; low‑sodium optional)
  • 2.5 oz Bacon Bits (Store‑bought; can substitute cooked crumbled bacon)
  • 1 packet Ranch Seasoning Mix (Typical 1‑oz packet)
  • 1 tsp All‑Purpose Seasoning (Optional extra flavor boost)
  • 1 cup Sharp Cheddar Cheese (Shredded)
  • 1.5 cups Sour Cream (Full‑fat for best texture)
  • 1 package Pillsbury Grands Biscuits (8 biscuits; can use any refrigerated biscuit dough)
  • 2 tbsp Fresh Parsley (Chopped, for garnish)
  • 1 spray Cooking Spray (To grease casserole dish)

Instructions

  1. Preheat Oven

    Set the oven to 350°F and allow it to preheat while you prepare the casserole.

    Time: PT10M

    Temperature: 350°F

  2. Shred Chicken

    Remove the breast meat from a rotisserie chicken and shred it into a large mixing bowl until you have about 3 cups.

    Time: PT5M

  3. Combine Base Ingredients

    Add the two cans of cream of chicken soup, 2.5 oz bacon bits, the ranch seasoning packet, 1 tsp all‑purpose seasoning, 1 cup shredded cheddar, and 1½ cups sour cream to the bowl. Stir until everything is evenly incorporated.

    Time: PT5M

  4. Cut Biscuits

    Open the biscuit package. Using a knife, cut each biscuit into eight bite‑size pieces (first cut in half, then quarters, then each quarter in half).

    Time: PT5M

  5. Fold Biscuits Into Mixture

    Gently fold the biscuit pieces into the chicken mixture until they are just coated.

    Time: PT2M

  6. Prepare Casserole Dish

    Spray the 9x13‑inch casserole dish with cooking spray. Transfer the entire mixture into the dish, spreading it out evenly and patting lightly with the back of a spoon.

    Time: PT3M

  7. Add Topping Cheese

    Sprinkle an additional ½ cup shredded cheddar over the top for extra melt and color.

    Time: PT2M

  8. Bake

    Place the dish in the preheated oven and bake uncovered for 40 minutes, or until the top is golden and the biscuits have puffed up.

    Time: PT40M

    Temperature: 350°F

  9. Garnish

    Remove the casserole from the oven and sprinkle chopped fresh parsley over the surface.

    Time: PT2M

  10. Rest and Serve

    Allow the casserole to rest for 5 minutes before serving so it sets and is easier to cut.

    Time: PT5M

Nutrition Facts

Calories
460
Protein
28 g
Carbohydrates
32 g
Fat
26 g
Fiber
2 g

Dietary info: Can be made gluten‑free with GF biscuit dough, Can be dairy‑free using plant‑based sour cream and cheese alternatives

Allergens: Dairy, Gluten, Egg

Last updated: March 13, 2026

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Easy Cheesy Bubble Up Chicken Casserole

Recipe by TENNESSEE NIKKI

A quick and comforting Southern-style casserole that combines shredded rotisserie chicken, creamy soup, bacon bits, ranch seasoning, sour cream, and fluffy biscuit pieces. Baked until golden and bubbly, this one‑dish dinner is perfect for busy weeknights.

EasySouthern AmericanServes 6

Shop all ingredients on Amazon in one click • Printable PDF with shopping checklist

Source Video
36m
Prep
43m
Cook
10m
Cleanup
1h 29m
Total

Cost Breakdown

$15.49
Total cost
$2.58
Per serving

Critical Success Points

  • Mixing the chicken, soups, and dairy together thoroughly (Step 3).
  • Ensuring biscuits are evenly distributed and not over‑mixed (Steps 4‑5).
  • Baking for the full 40 minutes at 350°F to achieve a golden, bubbly top (Step 8).

Safety Warnings

  • Use oven mitts when handling the hot casserole dish.
  • Beware of steam when removing the dish from the oven.

Frequently Asked Questions

Everything you need to know about this recipe

Q

What is the cultural significance and history of Chicken Biscuit Bubble-Up Casserole in Southern American cuisine?

A

Chicken biscuit casseroles are a classic comfort food in the Southern United States, originating from the tradition of using pantry staples like canned soup, biscuits, and rotisserie chicken to create a hearty, one‑pot meal for busy families.

cultural
Q

What are the traditional regional variations of chicken biscuit casseroles in Southern cuisine?

A

In the Deep South, cooks often add corn kernels or diced green chilies, while in the Gulf Coast version you might find a splash of hot sauce or Creole seasoning. Some families use buttermilk biscuits instead of refrigerated dough for a richer texture.

cultural
Q

How is Chicken Biscuit Bubble-Up Casserole traditionally served in Southern households?

A

It is typically served hot straight from the oven, often accompanied by a simple green salad, pickles, or collard greens. A slice is cut, allowed to set for a few minutes, then plated with a side of cornbread or biscuits.

cultural
Q

What occasions or celebrations is Chicken Biscuit Bubble-Up Casserole associated with in Southern culture?

A

The dish is popular for casual family gatherings, potlucks, and weeknight meals. It also appears at church socials and backyard barbecues where a quick, crowd‑pleasing casserole is needed.

cultural
Q

How does Chicken Biscuit Bubble-Up Casserole fit into the broader Southern cuisine tradition?

A

It embodies the Southern emphasis on comfort, convenience, and using leftover or readily available ingredients. The combination of creamy sauce, tender chicken, and fluffy biscuits reflects the region’s love for rich, satisfying dishes.

cultural
Q

What are the authentic traditional ingredients for Chicken Biscuit Bubble-Up Casserole versus acceptable substitutes?

A

Traditional ingredients include rotisserie or boiled chicken, canned cream of chicken soup, refrigerated biscuit dough, sour cream, and sharp cheddar. Substitutes can be homemade cream soup, cooked chicken breast, gluten‑free biscuits, Greek yogurt for sour cream, or any meltable cheese.

cultural
Q

What other Southern dishes pair well with Chicken Biscuit Bubble-Up Casserole?

A

Pairs nicely with buttery corn on the cob, collard greens sautéed with ham hocks, a fresh cucumber‑tomato salad, or classic Southern biscuits and honey butter.

cultural
Q

What makes Chicken Biscuit Bubble-Up Casserole special or unique in Southern cuisine?

A

The ‘bubble‑up’ effect comes from the biscuit pieces puffing and creating a light, airy topping that contrasts with the creamy, savory base, giving the dish a textural surprise that’s both comforting and novel.

cultural
Q

What are the most common mistakes to avoid when making Chicken Biscuit Bubble-Up Casserole?

A

Common errors include over‑mixing the biscuit pieces, not preheating the oven fully, and baking uncovered for too long which can dry the top. Keep the biscuits gently folded in and bake at the correct temperature for the full 40 minutes.

technical
Q

How do I know when Chicken Biscuit Bubble-Up Casserole is done cooking?

A

The casserole is done when the top is golden‑brown, the biscuits have puffed up and are firm to the touch, and a knife inserted into the center comes out hot with only a few moist crumbs.

technical
Q

Can I make Chicken Biscuit Bubble-Up Casserole ahead of time and how should I store it?

A

Yes, you can assemble the casserole up to the point of adding the final cheese topping, cover, and refrigerate for up to 24 hours. Bake it directly from the fridge, adding a few extra minutes to the bake time.

technical
Q

What does the YouTube channel TENNESSEE NIKKI specialize in?

A

The YouTube channel TENNESSEE NIKKI focuses on easy, family‑friendly Southern comfort food recipes, quick weeknight meals, and budget‑friendly cooking tips presented with a warm, down‑home style.

channel
Q

How does the YouTube channel TENNESSEE NIKKI's approach to Southern cooking differ from other Southern cooking channels?

A

TENNESSEE NIKKI emphasizes ultra‑quick preparation using store‑bought shortcuts like rotisserie chicken and pre‑made biscuit dough, while still delivering authentic Southern flavors, whereas many other channels focus on made‑from‑scratch techniques.

channel

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